Background The relationship between surgery and anesthetic-induced immunosuppression
and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the …

This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2017. Other selected articles can be found online at http://ccforum …

Suppression of the immune system has been constantly reported in the last years as a
classical side effect of opioid drugs. Most of the studies on the immunological properties of …

Preclinical and clinical studies have sought to better understand the effect of anesthetic
agents, both volatile and intravenous, and perioperative adjuvant medications on immune …

Background The optimal combination of anesthetic agent and technique may have an
influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that …

Background Vascular endothelial growth factor (VEGF) and transforming growth factor-β
(TGF-β) have been involved in tumor growth and metastasis. Sevoflurane may promote …

Sedatives exert profound effects on the central nervous system yet their effects on other
organ systems are potentially underappreciated. The immunologic effects of sedation fall …

This review provides an overview of the immunological effects of commonly used analgesic
opioid drugs, focusing mainly on two aspects: the mechanisms involved and the potential …

General anaesthesia accompanied by surgical stress may influence the inflammatory
responses that are essential for maintaining the homeostatic state during the postoperative …

Tumor recurrences or metastases remain a major hurdle in improving overall cancer
survival. In the perioperative period, the balance between the ability of the cancer to seed …