Obesity and diabetes

C Boutari, A DeMarsilis, CS Mantzoros - Diabetes Research and Clinical …, 2023 - Elsevier
Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

Liver fat as risk factor of hepatic and cardiometabolic diseases

M Demir, SR Bornstein, CS Mantzoros… - Obesity …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

B Chong, G Kong, K Shankar, HSJ Chew, C Lin, R Goh… - Metabolism, 2023 - Elsevier
Background A significant proportion of premature deaths globally are related to metabolic
diseases in young adults. We examined the global trends and mortality of metabolic …

ROS and RNS modulation: the main antimicrobial, anticancer, antidiabetic, and antineurodegenerative mechanisms of metal or metal oxide nanoparticles

M Alavi, R Yarani - Nano Micro Biosystems, 2023 - nmb-journal.com
Severe side effects of chemotherapeutic and anti-diabetic drugs for cancer cells and type 2
diabetes (T2D) type and emerging drug resistance in pathogenic microorganisms …

PRDM16 exerts critical role in myocardial metabolism and energetics in type 2 diabetes induced cardiomyopathy

T Hu, Q Wu, Q Yao, J Yu, K Jiang, Y Wan, Q Tang - Metabolism, 2023 - Elsevier
Background The prevalence of type 2 diabetes mellitus (T2DM) has increased over the past
decades. Diabetic cardiomyopathy (DCM) is the leading cause of death in T2DM patients …

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

DM Ferreira, NM de Oliveira, MH Chéu, D Meireles… - Plants, 2023 - mdpi.com
Olea europaea L. folium merits further exploration of the potential of its substrates for
therapeutic supplements. Quantitative and qualitative analyses were conducted on samples …

Recent research advances in metabolism, clinical and experimental

C Boutari, M Kokkorakis, K Stefanakis… - Metabolism, 2023 - Elsevier
Metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and non-
alcoholic fatty liver disease (NAFLD)–henceforth named metabolic dysfunction-associated …

Plasma proteome profiling reveals the therapeutic effects of the PPAR pan-agonist chiglitazar on insulin sensitivity, lipid metabolism, and inflammation in type 2 …

X Wang, Y Wang, J Hou, H Liu, R Zeng, X Li, M Han… - Scientific Reports, 2024 - nature.com
Chiglitazar is a novel peroxisome proliferator-activated receptor (PPAR) pan-agonist, which
passed phase III clinical trials and was newly approved in China for use as an adjunct to diet …

Essential oil from Fructus Alpinia zerumbet ameliorates atherosclerosis by activating PPARγ-LXRα-ABCA1/G1 signaling pathway

S Wang, J Xiang, G Zhang, L Fu, Y Xu, Y Chen, L Tao… - Phytomedicine, 2024 - Elsevier
Background Atherosclerosis (AS) is a progressive chronic disease. Currently, cardiovascular
diseases (CVDs) caused by AS is responsible for the global increased mortality …

Clinical pharmacology of antidiabetic drugs: What can be expected of their use?

AJ Scheen - La Presse Médicale, 2023 - Elsevier
The pharmacotherapy of type 2 diabetes mellitus (T2DM) has markedly evolved in the last
two decades. Classical antidiabetic agents (sulphonylureas, metformin, insulin) are now in …