Background Combining hemodialysis treatment with hemoperfusion (HP) can lower the
cardiovascular-related mortality rate of patients with kidney failure. Methods In this study, we …

Improving outcomes by manipulating the prescription of renal replacement therapy to
increase the removal of uremic toxins has had limited success. Failure to achieve better …

Hemodiafiltration (HDF) is an extracorporeal renal-replacement technique using a highly
permeable membrane, in which diffusion and convection are conveniently combined to …

Purpose Indoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention
solutes whose levels can be partially reduced by renal replacement therapy. These solutes …

Uremic toxins (UTs), particularly protein-bound uremic toxins (PBUTs), accumulate in
chronic kidney disease (CKD) patients, causing significant health complications like uremic …

Many hypotheses could explain the mortality decrease observed using hemodiafiltration,
such as reduction of intradialytic hypotension and more efficient toxin removal. We led a …

Background Conventional hemodialysis provides limited clearance of uremic solutes that
bind to plasma proteins. However, no studies have tested whether increasing the clearance …

In the course of severe pathological conditions, such as acute liver failure and sepsis, toxic
metabolites and mediators of inflammation are released into the patient's circulation. One …

Patients with chronic kidney disease (CKD) often exhibit increased level of oxidative stress
that contribute to the deterioration of renal function and uremic complications. White adipose …

Patients with end-stage kidney disease undergoing chronic hemodialysis (HD) present
higher mortality rates compared with the general population. Once patients are on HD, the …