Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease,
affecting approximately one-quarter of the global population, and has become a world public …

The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD‐related
cirrhosis in the United States and globally highlights the need to better understand the …

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of hepatic
histopathological changes ranging from non-inflammatory intracellular fat deposition to non …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome. The underlying causes of the disease progression in NAFLD are unclear. Recent …

Emerging experimental and human evidence has linked altered hepatic cholesterol
homeostasis and free cholesterol (FC) accumulation to the pathogenesis of non-alcoholic …

The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all
aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of …

Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated
transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master …

Reactive oxygen species, when released under controlled conditions and limited amounts,
contribute to cellular proliferation, senescence, and survival by acting as signaling …

The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and
secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded …