Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

Mitochondria are dynamic, multifunctional cellular organelles that play a fundamental role in
maintaining cellular homeostasis. Keeping the quality of mitochondria in check is of …

Introduction Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer's
disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

The genetics and pathophysiology of Parkinson's disease (PD) strongly implicate
mitochondria in disease aetiology. Elegant studies over the last two decades have …

SARS-CoV-2 is a positive sense RNA coronavirus that constitutes a new threat for the global
community and economy. While vaccines against SARS-CoV-2 are being developed, the …

Arsenic and antimony are coexisting cumulative environmental pollutants that cause severe
and extensive biological toxicity. However, their interactions and toxic mechanisms in the …

Healthy mitochondria are essential for functional bioenergetics, calcium signaling, and
balanced redox homeostasis. Dysfunctional mitochondria are a central aspect of aging and …

Selective autophagy of mitochondria, mitophagy, is linked to mitochondrial quality control
and as such is critical to a healthy organism. We have used a CRISPR/Cas9 approach to …