The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

A dynamic and mutualistic interaction between tumour cells and the surrounding stroma
promotes the initiation, progression, metastasis and chemoresistance of solid tumours. Far …

Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death.
The immune-rich contexture of the HCC microenvironment makes this tumour an appealing …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Abstract Knowledge of the immunological events necessary to control hepatitis B virus
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …

The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

The liver is a central immunological organ. Liver resident macrophages, Kupffer cells (KC),
but also sinusoidal endothelial cells, dendritic cells (DC) and other immune cells are …

Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide.
Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is …

Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …