Research on mesoscale nucleation and growth processes in solution crystallization: A review

X Wang, K Li, X Qin, M Li, Y Liu, Y An, W Yang, M Chen… - Crystals, 2022 - mdpi.com
In recent studies, the existence of mesoscale precursors has been confirmed in
crystallization. Different from the classical crystallization theory, which only considers the …

Crystal growth kinetics of an industrial active pharmaceutical ingredient: Implications of different representations of supersaturation and simultaneous growth …

GL Quilló, S Bhonsale, B Gielen… - Crystal Growth & …, 2021 - ACS Publications
The crystal growth kinetics of a proprietary active pharmaceutical ingredient (API) was
investigated by isothermal seeded batch de-supersaturation experiments in solvent mixtures …

Influence mechanism of polymeric excipients on drug crystallization: Experimental investigation and chemical potential gradient model analysis and prediction

Q Chen, J Weng, G Sadowski, Y Ji - Crystal Growth & Design, 2023 - ACS Publications
In this work, the influence of temperature, stirring speed, and polymeric excipients on crystal
growth kinetics of active pharmaceutical ingredients (APIs) mesalazine and allopurinol was …

Crystallization kinetics and mechanisms of calcium sulfate dihydrate: experimental investigation and theoretical analysis

S Tang, Y Ji, K Ge - Industrial & Engineering Chemistry Research, 2020 - ACS Publications
In this work, four influencing factors including temperature, stirring speed, pH value, and
polymer concentration were chosen to investigate crystallization kinetics of calcium sulfate …

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

A Haghighizadeh, H Mahdavi… - Chemical Engineering & …, 2024 - Wiley Online Library
Continuous crystallization of pharmaceuticals has been in the center of attention during the
past two decades, with a more focus on the large‐scale production of active pharmaceutical …

Solvent–Antisolvent Competitive Interactions Mediate Imidacloprid Polymorphs in Antisolvent Crystallization

S Xue, J Xu, Y Han, J Zhang, W Li - Crystal Growth & Design, 2021 - ACS Publications
Imidacloprid (IMI) polymorphs were first found to be sensitive to the content of antisolvent in
an antisolvent crystallization process using formic acid (FA) as a solvent and water (W) as an …

Determination of the metastable zone and induction time of thiourea for cooling crystallization

T Zhou, C Tu, Y Sun, L Ji, C Bian, X Lu… - Chinese Journal of …, 2021 - Elsevier
The solubility, metastable zone width (MSZW), and induction time of thiourea for cooling
crystallization were experimentally determined in the temperature range of 283–323 K. The …

Influence of high pressure on the solubility of ribavirin in six pure solvents from 283.15 to 323.15 K

Y Feng, H Hao, B Tian, K Chen, N Wang… - The Journal of Chemical …, 2022 - Elsevier
The solubility of ribavirin in six pure solvents was measured at 9.0 MPa and 0.1 MPa to
evaluate the influence of high pressure on solubility at the temperature range from 283.15 K …

Insights into influence mechanism of polymeric excipients on dissolution of drug formulations: A molecular interaction‐based theoretical model analysis and prediction

Y Ji, D Hao, C Luebbert, G Sadowski - AIChE Journal, 2021 - Wiley Online Library
This study provides an analysis of the dissolution mechanism of poorly water‐soluble drugs,
indomethacin (IND) and naproxen (NAP), from polyvinyl acetate (PVAc) and …

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

X Zhong, Y Guo, B Bao - Industrial & Engineering Chemistry …, 2024 - ACS Publications
The semicontinuous antisolvent crystallization process of pyraclostrobin was investigated
utilizing an integrated microfluidic device that encompasses both microfluidic channels and …