A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

[HTML][HTML] Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

S Halldorsson, E Lucumi, R Gómez-Sjöberg… - Biosensors and …, 2015 - Elsevier
Culture of cells using various microfluidic devices is becoming more common within
experimental cell biology. At the same time, a technological radiation of microfluidic cell …

From 3D cell culture to organs-on-chips

D Huh, GA Hamilton, DE Ingber - Trends in cell biology, 2011 - cell.com
3D cell-culture models have recently garnered great attention because they often promote
levels of cell differentiation and tissue organization not possible in conventional 2D culture …

Reconstituting organ-level lung functions on a chip

D Huh, BD Matthews, A Mammoto, M Montoya-Zavala… - Science, 2010 - science.org
Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-
capillary interface of the human lung. This bioinspired microdevice reproduces complex …

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

J Friend, LY Yeo - Reviews of Modern Physics, 2011 - APS
This article reviews acoustic microfluidics: the use of acoustic fields, principally ultrasonics,
for application in microfluidics. Although acoustics is a classical field, its promising, and …

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling

EGZ Centeno, H Cimarosti, A Bithell - Molecular neurodegeneration, 2018 - Springer
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …

[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation

S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Recent progress in translational engineered in vitro models of the central nervous system

P Nikolakopoulou, R Rauti, D Voulgaris, I Shlomy… - Brain, 2020 - academic.oup.com
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Cell-based biosensors and their application in biomedicine

Q Liu, C Wu, H Cai, N Hu, J Zhou, P Wang - Chemical reviews, 2014 - ACS Publications
A biosensor is an analytical device that can be used for detecting analytes and combines a
biological component with a physicochemical detecting transducer. In recent years …

Microfluidic devices for bioapplications

LY Yeo, HC Chang, PPY Chan, JR Friend - small, 2011 - Wiley Online Library
Harnessing the ability to precisely and reproducibly actuate fluids and manipulate
bioparticles such as DNA, cells, and molecules at the microscale, microfluidics is a powerful …