Since the divergence of humans and chimpanzees about 5 million years ago, these species
have undergone a remarkable evolution with drastic divergence in anatomy and cognitive …

Defective sperm function is the largest single defined cause of human infertility and one of
the major reasons we are witnessing an exponential increase in the uptake of assisted …

BACKGROUND The human sperm cell is very well suited for proteomic studies, as it is
accessible, can be easily purified and is believed to be transcriptionally and translationally …

Protein ubiquitination is a reversible reaction, in which the ubiquitin chains are
deconjugated by a family of deubiquitinases (DUBs). The presence of a large number of …

The molecular basis of many forms of male infertility is poorly defined. One area of research
that has been studied intensely is the integrity of the DNA in the nucleus of mature …

BACKGROUND: The relationship between early embryo post-implantation development in
couples undergoing assisted reproductive techniques (ARTs) and sperm chromatin …

Male factor infertility is the sole cause of infertility in approximately 20% of infertile couples,
with an additional 30% to 40% secondary to both male and female factors. Current means of …

Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is
considered the cornerstone of laboratory evaluation of male infertility, but it has its own …

BACKGROUND: Sperm cell death appears to be a cause of male infertility. The objective of
this study was to determine the most reliable method for the evaluation of sperm quality in …

Human spermatozoa are characterized by poor functionality and abundant DNA damage
that collude to generate the high incidences of male infertility and miscarriage seen in our …