Highlights•Sperm nuclear and chromatin abnormalities are common among infertile men
and are known to influence natural reproduction.•The haploid paternal genome provides the …

OBJECTIVE: To investigate sperm DNA damage in relation to fertilization and pregnancy.
DESIGN: Prospective study. SETTING: The Institute of Reproductive Medicine, Giessen …

During early development, apoptosis plays a major role in the ontogeny of the germ line as a
means of regulating the germ cell: Sertoli cell ratio. In the adult, apoptosis fulfils another …

BACKGROUND: The pathophysiology of the testicular damage in varicocele has not been
completely understood. Oxidative stress and related sperm DNA damage have been …

During the elongating spermatid stage of spermiogenesis, human sperm chromatin
undergoes a complex transition in which histones are extensively replaced by protamines in …

Short term exposure of the testis to heat causes degeneration of germ cells. However, the
mechanisms underlying this process are poorly understood. The major objectives of this …

Formation of the male gamete occurs in sequential mitotic, meiotic, and postmeiotic phases.
Many germ cell-specific transcripts are produced during this process. Their expression is …

The mammalian seminiferous epithelium consists of a highly complex yet well-organized
cell population, with germ cells in mitosis and meiosis and postmeiotic cells undergoing …

Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal
genetic information, and normal sperm chromatin structure is important for sperm fertilizing …

Bcl-2, Bcl-X L, and Bax are members of the Bcl-2 family that play important roles in apoptosis
regulation. These proteins are believed to be membrane-bound and to regulate apoptosis …