Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal
genetic information, and normal sperm chromatin structure is important for sperm fertilizing …

The differentiation of primordial germ cells (PGCs) into functional oocytes is important for the
continuation of species. In mammals, PGCs begin to differentiate into oocytes during …

Short term exposure of the testis to heat causes degeneration of germ cells. However, the
mechanisms underlying this process are poorly understood. The major objectives of this …

The origin and development of the spermatogenic cell lineage is reviewed, as well as
spermatogonial kinetics in adult nonprimate mammals in relation to the cycle of the …

The life cycle of many cell types can hinge on the presence of death factors that can control
programmed cell death. The Fas-mediated apoptotic pathway has been implicated in …

The mechanisms responsible for producing abnormal spermatozoa in the ejaculate are
relatively unknown. Numerous studies have now shown the presence of nuclear DNA strand …

Male germ cells, the repository cells of the genome, comprise several successive
developmental stages starting in the embryo and ending up with the spermatozoon …

Despite the ever-increasing knowledge of the fertilization process, there is still a need for
better understanding of the causes of sperm DNA fragmentation and its impact on …

Male reproductive health has deteriorated considerably in the last few decades. Nutritional,
socioeconomic, lifestyle and environmental factors (among others) have been attributed to …

In the course of mammalian spermiogenesis, a unique chromatin remodeling process takes
place within elongating and condensing spermatid nuclei. The histone-to-protamine …