In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the
spectrum of different forms of regulated cell death (RCD) has expanded dramatically with …

Many studies have shown how a 'paternal effect'can cause repeated assisted reproduction
failures. In particular, with increasing experience of intracytoplasmic sperm injection (ICSI), it …

Dysregulation of male germ cell apoptosis has been associated with the pathogenesis of
male infertility. Therefore, factors involved in the regulation of germ cell death are being …

The purpose of the present study was to examine the possible involvement of caspase-3
and caspase-activated deoxyribonuclease in rat testicular germ cell apoptosis resulting from …

Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory
caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates …

Elimination of germ cells via apoptosis occurs spontaneously under normal physiologic
conditions and is often heightened after chemical-induced testicular injury. Though many …

Stem cell factor (SCF) plays an important role in migration, adhesion, proliferation, and
survival of primordial germ cells and spermatogonia during testicular development …

ABSTRACT The Fas/FasL signaling pathway is one of the major pathways that regulate
apoptosis. Increasing studies have shown that the activation of the Fas/FasL signaling …

In naturally occurring mutant mice but also in mice genetically modified for the study of other
organs, relatively often a spermatogenic arrest is seen. In a number of cases the arrests …

Acrylamide (AA) is a common chemical, produced during food processing and widely used
in various industries and laboratory processes. Thus, AA causes a significant risk for human …