Bcl-w, a prosurvival member of the Bcl-2 family, is essential for spermatogenesis. However,
the mechanisms by which Bcl-w participates in the regulation of apoptosis in the testis are …

The purpose of this chapter is to provide a comprehensive overview of spermatogenesis and
the various steps involved in the development of the male gamete, including cellular …

Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory
caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates …

Abstract Connexin43 (Cx43), a gap junction protein encoded by the Gja1 gene, is expressed
in several cell types of the testis. Cx43 gap junctions couple Sertoli cells with each other …

OBJECTIVE: Potential reparation of sperm DNA fragmentation in the oocyte may disturb any
relationship between DNA-damaged sperm and the implantation ability of resulting …

The physiological apoptosis that occurs in immature testis appears to be necessary for the
maturation of this tissue. Thus, inhibition of the early apoptotic wave associated with the first …

Programmed cell death is an important regulatory event in spermatogenesis. However, the
molecular events governing apoptosis have not been characterized. Using the Leydig cell …

In many organisms, programmed cell death of germ cells is required for normal
development. This often occurs through highly conserved events including the transfer of …

Historically, the precursor cells to spermatogonia have been identified as “gonocytes,” a
term created in the fifties to encompass fetal and neonatal germ cells from the time they …

Zearalenone (ZEA), a nonsteroidal estrogenic mycotoxin, is known to cause toxicity of testis
in male rats. To investigate whether apoptosis is involved in ZEA-induced testicular toxicity …