Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and
this is indispensable for oocyte development and female fertility. Although the role of …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

The ovary is the first organ to age in humans with functional decline evident already in
women in their early 30s. Reproductive aging is characterized by a decrease in oocyte …

The polycystic ovarian syndrome (PCOS) is closely associated with enhanced apoptosis of
granulosa cells, which have a vital role in maturation of oocytes. p53 plays a critical role in …

Bisphenol A (BPA) is an endocrine disruptor strongly associated with ovarian dysfunction.
BPA is being substituted by structurally similar chemicals, such as bisphenol S (BPS) …

Objective To study the effect of aging and granulosa cell growth hormone receptor (GHR)
expression, and the effect of growth hormone (GH) co-treatment during IVF on receptor …