The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Cerebral blood flow (CBF) and cerebral autoregulation (CA) are critically important to
maintain proper brain perfusion and supply the brain with the necessary oxygen and energy …

Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of
homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the …

For 200 years, the 'closed box'analogy of intracranial pressure (ICP) has underpinned
neurosurgery and neuro-critical care. Cushing conceptualised the Monro-Kellie doctrine …

To establish the accuracy of transcranial Doppler ultrasound (TCD) measures of middle
cerebral artery (MCA) cerebral blood flow velocity (CBFV) as a surrogate of cerebral blood …

In the evaluation of cerebrovascular CO2 reactivity measurements, it is often assumed that
the diameter of the large intracranial arteries insonated by transcranial Doppler remains …