Background The pharmaceutical industry is in the midst of a productivity crisis and rates of
translation from bench to bedside are dismal. Patients are being let down by the current …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …

Abstract Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil
bacteria and originally developed as an anticancer agent, in 1963 has been found to induce …

Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology, target identification, and in the in vivo evaluation of novel …

Introduction Alzheimer's disease (AD) is increasing in frequency as the global population
ages. Five drugs are approved for treatment of AD, including four cholinesterase inhibitors …

Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
today. The search for new treatments is made ever more urgent by prospects for increasing …

The ε4 allele of the APOE gene encoding apolipoprotein E (apoE) is a strong genetic risk
factor for aging-related cognitive decline as well as late-onset Alzheimer's disease (AD) …

Despite dramatic advances in the molecular pathogenesis of disease, translation of basic
biomedical research into safe and effective clinical applications remains a slow, expensive …

Public acceptance of the use of animals in biomedical research is conditional on it
producing benefits for humans. Pandora Pound and Michael Bracken argue that the benefits …