Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

Thrombospondin 1 (TSP1) is a matricellular extracellular matrix protein that has diverse
roles in regulating cellular processes important for the pathogenesis of fibrotic diseases. We …

The extracellular matrix (ECM) is a biological substrate composed of collagens,
proteoglycans and glycoproteins that ensures proper cell migration and adhesion and keeps …

Abstract von Willebrand factor (VWF) and factor VIII (FVIII) circulate in a noncovalent
complex in blood and promote primary hemostasis and clotting, respectively. A new VWF A1 …

The crosstalk between tumor cells and the tumor microenvironment (TME), triggers a variety
of critical signaling pathways and promotes the malignant progression of cancer. The …

The lung displays a remarkable capability to regenerate following injury. Considerable effort
has been made thus far to understand the cardinal processes underpinning inflammation …

CCN proteins play important functions during development, in repair mechanisms following
tissue injury, as well as in pathophysiologic mechanisms of metastasis of cancer. CCNs are …

Critical limb ischemia (CLI) is caused by severe arterial blockage with reduction of blood
flow. The aim of this study was to determine whether therapeutic angiogenesis using cellular …

Abstract Purposeof the Review Hemostasis plays a central role in maintaining a normal
physiological vasculature, especially during and after vascular injury. Low-density …

Background The role of low-density lipoprotein receptor-related protein 1 (LRP1) in
Alzheimer's disease (AD) has been a focal point of research, highlighting its crucial function …