Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair

ME Hartman, DF Dai, MA Laflamme - Advanced drug delivery reviews, 2016 - Elsevier
Human pluripotent stem cells (PSCs) represent an attractive source of cardiomyocytes with
potential applications including disease modeling, drug discovery and safety screening, and …

Differences between human embryonic stem cell lines

C Allegrucci, LE Young - Human reproduction update, 2007 - academic.oup.com
The promise of human embryonic stem cell (hESC) lines for treating injuries and
degenerative diseases, for understanding early human development, for disease modelling …

Defined culture conditions of human embryonic stem cells

J Lu, R Hou, CJ Booth, SH Yang… - Proceedings of the …, 2006 - National Acad Sciences
Human embryonic stem cells (hESCs) are pluripotent cells that have the potential to
differentiate into any tissue in the human body; therefore, they are a valuable resource for …

Immunogenicity of pluripotent stem cells and their derivatives

PE de Almeida, JD Ransohoff, A Nahid… - Circulation research, 2013 - Am Heart Assoc
The ability of pluripotent stem cells to self-renew and differentiate into all somatic cell types
brings great prospects to regenerative medicine and human health. However, before clinical …

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies

JA Heslop, TG Hammond, I Santeramo… - Stem cells …, 2015 - academic.oup.com
The field of stem cell therapeutics is moving ever closer to widespread application in the
clinic. However, despite the undoubted potential held by these therapies, the balance …

[HTML][HTML] Mending a broken heart: current strategies and limitations of cell-based therapy

LC Liew, BX Ho, BS Soh - Stem Cell Research & Therapy, 2020 - Springer
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity
and plasticity, has sparked a considerable interest for potential application in regenerative …

Critical issues of clinical human embryonic stem cell therapy for brain repair

JY Li, NS Christophersen, V Hall, D Soulet… - Trends in …, 2008 - cell.com
Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for
neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC …

[HTML][HTML] Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach

D Moschidou, S Mukherjee, MP Blundell, K Drews… - Molecular Therapy, 2012 - cell.com
Induced pluripotent stem cells (iPSCs) with potential for therapeutic applications can be
derived from somatic cells via ectopic expression of a set of limited and defined transcription …

[HTML][HTML] Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems

N Desai, P Rambhia, A Gishto - Reproductive Biology and Endocrinology, 2015 - Springer
Human embryonic stem cells (hESC) have emerged as attractive candidates for cell-based
therapies that are capable of restoring lost cell and tissue function. These unique cells are …

Human ESC–derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration

K Ben M'Barek, W Habeler, A Plancheron… - Science translational …, 2017 - science.org
Replacing defective retinal pigment epithelial (RPE) cells with those derived from human
embryonic stem cells (hESCs) or human-induced pluripotent stem cells (hiPSCs) is a …