Immunogenicity of induced pluripotent stem cells

K Okita, N Nagata, S Yamanaka - Circulation research, 2011 - Am Heart Assoc
amelioration of the symptoms of rodent disease models after transplantation of iPSC-derived
differentiated cells. For example, hematopoietic stem cells and neuronal precursor cells from …

Concise review: clinical programs of stem cell therapies for liver and pancreas

G Lanzoni, T Oikawa, Y Wang, CB Cui, G Carpino… - Stem …, 2013 - academic.oup.com
Regenerative medicine is transitioning into clinical programs using stem/progenitor cell
therapies for repair of damaged organs. We summarize those for liver and pancreas, organs …

Clinical-grade human pluripotent stem cells for cell therapy: characterization strategy

D Rehakova, T Souralova, I Koutna - International Journal of Molecular …, 2020 - mdpi.com
Human pluripotent stem cells have the potential to change the way in which human
diseases are cured. Clinical-grade human embryonic stem cells and human induced …

The future of stem cell therapies of Alzheimer's disease

ZB Wang, ZT Wang, Y Sun, L Tan, JT Yu - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) places a heavy burden on the global economy. There is no
effective disease-modifying treatment available at present. Since the advent of induced …

Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures

DA Fluri, PD Tonge, H Song, RP Baptista, N Shakiba… - Nature …, 2012 - nature.com
We describe derivation of induced pluripotent stem cells (iPSCs) from terminally
differentiated mouse cells in serum-and feeder-free stirred suspension cultures. Temporal …

Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering

Y Jang, J Choi, N Park, J Kang, M Kim, Y Kim… - … & molecular medicine, 2019 - nature.com
Pluripotent stem cell transplantation is a promising regenerative strategy for treating
intractable diseases. However, securing human leukocyte antigen (HLA)-matched donor …

[HTML][HTML] Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer

K Kim, K Ng, PJ Rugg-Gunn, JH Shieh, O Kirak… - Cell stem cell, 2007 - cell.com
Parthenogenesis and somatic cell nuclear transfer (SCNT) are two methods for deriving
embryonic stem (ES) cells that are genetically matched to the oocyte donor or somatic cell …

Banking on iPSC-is it doable and is it worthwhile

S Solomon, F Pitossi, MS Rao - Stem Cell Reviews and Reports, 2015 - Springer
The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of
protocols for their cell-type specific differentiation have revolutionized studies of diseases …

Repurposing the cord blood bank for haplobanking of HLA-homozygous iPSCs and their usefulness to multiple populations

S Lee, JY Huh, DM Turner, S Lee, J Robinson… - Stem …, 2018 - academic.oup.com
Although autologous induced pluripotent stem cells (iPSCs) can potentially be useful for
treating patients without immune rejection, in reality it will be extremely expensive and labor …

The safety of human pluripotent stem cells in clinical treatment

OE Simonson, A Domogatskaya, P Volchkov… - Annals of …, 2015 - Taylor & Francis
Human pluripotent stem cells (hPSCs) have practically unlimited proliferation potential and a
capability to differentiate into any cell type in the human body. Since the first derivation in …