The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to
maintain and support the internal milieu of the islets favoring normal endocrine function. Islet …

Organoids, which exhibit spontaneous organ specific organization, function, and multi-
cellular complexity, are in essence the in vitro reproduction of specific in vivo organ systems …

The islets of Langerhans consist of endocrine cells embedded in a network of specialized
capillaries that regulate islet blood flow. Despite evidence for a critical role of islet perfusion …

The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …

The β-cells of the islets of Langerhans are embedded in a dense capillary network. The
blood vessels supply the islet cells with nutrients and oxygen, and in turn take up the …

The cross-talk between beta cells and endothelium plays a key role in islet physiopathology
and in the revascularization process after islet transplantation. However, the molecular …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …

Hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGFA) are
paracrine hormones that mediate communication between pancreatic islet endothelial cells …