Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): an updated review
The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
Furan and benzofuran derivatives as privileged scaffolds as anticancer agents: SAR and docking studies (2010 to till date)
Furan and benzofuran scaffolds are privileged and well-studied heterocyclic rings for
designing and developing new potential anticancer compounds. Previous literature showed …
designing and developing new potential anticancer compounds. Previous literature showed …
Discovery of (quinazolin-6-yl) benzamide derivatives containing a 6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline moiety as potent reversal agents against P …
W Xue, K Liu, T Zhang, G Dong, J Wang, J Wang… - European Journal of …, 2024 - Elsevier
Abstract P-glycoprotein (P-gp) is an important factor leading to multidrug resistance (MDR)
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …
Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell
Z Yang, D Luo, C Shao, H Hu, X Yang, Y Cai… - European Journal of …, 2024 - Elsevier
The inhibition of P-glycoprotein (P-gp) has emerged as an intriguing strategy for
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
Discovery of 2, 5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell
Z Yang, Y Cai, S Mao, Q Wu, M Zhu, X Cao… - European Journal of …, 2023 - Elsevier
Abstract P-glycoprotein (P-gp) is one of the drug efflux transporters that triggers multidrug
resistance (MDR) in cells. Herein, by utilizing the strategies of active skeleton splicing and …
resistance (MDR) in cells. Herein, by utilizing the strategies of active skeleton splicing and …
Recent developments of P-glycoprotein inhibitors and its structure–activity relationship (SAR) studies
X Zhao, J Di, D Luo, Y Vaishnav, N Nuralieva… - Bioorganic …, 2023 - Elsevier
Abstract P-glycoprotein (P-gp) over-expression is a key factor in multi-drug resistance
(MDR), which is a major factor in the failure of cancer treatment. P-gp inhibitors have been …
(MDR), which is a major factor in the failure of cancer treatment. P-gp inhibitors have been …
Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
J Laiolo, DG Graikioti, CL Barbieri, MB Joray… - Scientific Reports, 2024 - nature.com
Chemotherapy is a powerful means of cancer treatment but its efficacy is compromised by
the emergence of multidrug resistance (MDR), mainly linked to the efflux transporter …
the emergence of multidrug resistance (MDR), mainly linked to the efflux transporter …
Recent advances on anticancer and antimicrobial activities of directly-fluorinated five-membered heterocycles and their benzo-fused systems
Due to the importance of the fluorinated heterocycles as main components of marketed
drugs where 20% of the anticancer and antibiotic drugs contain fluorine atoms, this review …
drugs where 20% of the anticancer and antibiotic drugs contain fluorine atoms, this review …
Design, synthesis, and biological evaluation of marine lissodendrins B analogues as modulators of ABCB1-mediated multidrug resistance
C Wang, J Zhang, X Wei, M Yang, W Ma, R Yu, M Liu… - Marine Drugs, 2023 - mdpi.com
Multidrug resistance (MDR) caused by ATP-Binding Cassette Subfamily B Member 1
(ABCB1, P-glycoprotein, P-gp) is a major barrier for the success of chemotherapy in clinics …
(ABCB1, P-glycoprotein, P-gp) is a major barrier for the success of chemotherapy in clinics …
Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance
L Yu, R Ren, S Li, C Zhang, C Chen, H Lv, Z Zou… - European Journal of …, 2024 - Elsevier
P-glycoprotein (Pgp) modulators are promising agents for overcoming multidrug resistance
(MDR) in cancer chemotherapy. In this study, via structural optimization of our lead …
(MDR) in cancer chemotherapy. In this study, via structural optimization of our lead …