Origin and functional role of antisense transcription in endogenous and exogenous retroviruses
F Romerio - Retrovirology, 2023 - Springer
Most proteins expressed by endogenous and exogenous retroviruses are encoded in the
sense (positive) strand of the genome and are under the control of regulatory elements …
sense (positive) strand of the genome and are under the control of regulatory elements …
[HTML][HTML] Non-coding natural antisense transcripts: Analysis and application
JC Krappinger, L Bonstingl, K Pansy, K Sallinger… - Journal of …, 2021 - Elsevier
Non-coding natural antisense transcripts (ncNATs) are regulatory RNA sequences that are
transcribed in the opposite direction to protein-coding or non-coding transcripts. These …
transcribed in the opposite direction to protein-coding or non-coding transcripts. These …
Upregulation of 15 antisense long non-coding RNAs in osteosarcoma
The human genome encodes thousands of natural antisense long noncoding RNAs
(lncRNAs); they play the essential role in regulation of gene expression at multiple levels …
(lncRNAs); they play the essential role in regulation of gene expression at multiple levels …
Novel perspectives on antisense transcription in HIV-1, HTLV-1, and HTLV-2
The genome of retroviruses contains two promoter elements (called long terminal repeat or
LTR) at the 5′ and 3′ end of their genome. Although the expression of retroviral genes …
LTR) at the 5′ and 3′ end of their genome. Although the expression of retroviral genes …
Epigenetic regulation of HIV-1 sense and antisense transcription in response to latency-reversing agents
Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense
transcription as well as the establishment and maintenance of latency. A negative-sense …
transcription as well as the establishment and maintenance of latency. A negative-sense …
[HTML][HTML] Tuning Rex rules HTLV-1 pathogenesis
K Nakano, T Watanabe - Frontiers in Immunology, 2022 - frontiersin.org
HTLV-1 is an oncovirus causing ATL and other inflammatory diseases such as HAM/TSP
and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells …
and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells …
Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells
M Estevez, R Li, B Paul, K Daneshvar, AC Mullen… - RNA, 2022 - rnajournal.cshlp.org
The human immunodeficiency virus type 1 (HIV-1) encodes multiple RNA molecules.
Transcripts that originate from the proviral 5′ long terminal repeat (LTR) function as …
Transcripts that originate from the proviral 5′ long terminal repeat (LTR) function as …
Chronic HIV Transcription, Translation, and Persistent Inflammation
JM Kilroy, AA Leal, AJ Henderson - Viruses, 2024 - mdpi.com
People with HIV exhibit persistent inflammation that correlates with HIV-associated
comorbidities including accelerated aging, increased risk of cardiovascular disease, and …
comorbidities including accelerated aging, increased risk of cardiovascular disease, and …
Creation of the HIV-1 antisense gene asp coincided with the emergence of the pandemic group M and is associated with faster disease progression
A Pavesi, F Romerio - Microbiology Spectrum, 2024 - Am Soc Microbiol
Despite being first identified more than three decades ago, the antisense gene asp of HIV-1
remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is …
remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is …
[HTML][HTML] Humanized mouse models for preclinical evaluation of HIV cure strategies
S Fraker, B Atkinson, A Heredia - AIDS reviews, 2022 - ncbi.nlm.nih.gov
Although the world is currently focused on the COVID-19 pandemic, HIV/AIDS remains a
significant threat to public health. To date, the HIV/AIDS pandemic has claimed the lives of …
significant threat to public health. To date, the HIV/AIDS pandemic has claimed the lives of …