Role of pyroptosis in inflammation and cancer
X Wei, F Xie, X Zhou, Y Wu, H Yan, T Liu… - Cellular & molecular …, 2022 - nature.com
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …
Interplay between NLRP3 inflammasome and autophagy
M Biasizzo, N Kopitar-Jerala - Frontiers in Immunology, 2020 - frontiersin.org
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
Inflammatory caspases: toward a unified model for caspase activation by inflammasomes
Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …
Inflammasomes as therapeutic targets in human diseases
Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - Signal transduction and …, 2021 - nature.com
Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …
inflammation in response to either exogenous pathogens or endogenous danger signals …
Neuroinflammation in Alzheimer's disease
IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …
NF-κB signaling in inflammation
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …
An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway
Z Feng, G Chen, M Zhong, L Lin, Z Mai, Y Tang… - Biomaterials, 2023 - Elsevier
Pyroptosis is an inflammatory form of programmed cell death (PCD) that is regulated by the
Gasdermin protein family in response to various stimuli, playing a critical role in the …
Gasdermin protein family in response to various stimuli, playing a critical role in the …
Cell biology of inflammasome activation
Organelles are critical structures in mediating the assembly and activation of
inflammasomes in mammalian cells, resulting in inflammation and cell death. Assembly of …
inflammasomes in mammalian cells, resulting in inflammation and cell death. Assembly of …
Cell death mediated by the pyroptosis pathway with the aid of nanotechnology: prospects for cancer therapy
Pyroptosis, a unique form of programmed cell death (PCD) that is characterized by DNA
fragmentation, chromatin condensation, cellular swelling with big bubbles, and leakage of …
fragmentation, chromatin condensation, cellular swelling with big bubbles, and leakage of …
The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease
S Wang, YH Yuan, NH Chen, HB Wang - International …, 2019 - Elsevier
Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological
feature of which is the death of dopamine neurons in the substantia nigra region. At present …
feature of which is the death of dopamine neurons in the substantia nigra region. At present …