Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …

Periodontitis is an inflammatory disease characterized by the destruction of the
periodontium. In the last decade, a new murine model of periodontitis has been widely used …

A hallmark of metazoan evolution is the emergence of genomic mechanisms that implement
cell-type-specific functions. However, the evolution of metazoan cell types and their …

Epithelial–mesenchymal transition (EMT) in carcinoma cells enhances malignant
progression by promoting invasion and survival. EMT is induced by microenvironmental …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Pseudostratified airway epithelium of the lung is composed of polarized ciliated and
secretory cells maintained by basal stem/progenitor cells. An important question is how …

Chromatin is a barrier to the binding of many transcription factors. By contrast, pioneer
factors access nucleosomal targets and promote chromatin opening. Despite binding to …

Oral mucosa provides the first line of defense against a diverse array of environmental and
microbial irritants by forming the barrier of epithelial cells interconnected by multiprotein tight …

The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

Epithelial immunity protects the host from harmful microbial invaders but also controls the
beneficial microbiota on epithelial surfaces. When this delicate balance between pathogen …