Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which
may not fully reflect immune responses at the site of infection. Using samples from 110 …

Purpose: We report the results of a phase II, randomized, window-of-opportunity trial of
neoadjuvant durvalumab versus durvalumab plus tremelimumab followed by surgery in …

Objective This study aimed to identify changes in T-cell factor-1 (TCF1) in circulating T-cell
subsets of systemic lupus erythematosus (SLE) patients and to explore their significance in …

Optimal T follicular helper (Tfh) cells function is important to promote the development of
germinal centers and maturation of high affinity antigen-specific B cells. We have found that …

CD4 T cells are key mediators of adaptive immune responses during infection and
vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly those …

Secondary human lymphoid tissue immune reactions take place in a highly coordinated
environment with compartmentalization representing a fundamental feature of this …

Introduction During the last century, changes in hygiene, sanitation, and the advent of
childhood vaccination have resulted in profound reductions in mortality from infectious …

Follicular helper CD4hi T cells (TFH) are a major cellular pool for the maintenance of the HIV
reservoir. Therefore, the delineation of the follicular (F)/germinal center (GC) immune …

The development of an effective humoral response to pathogens and immunogens is a
multiphase biological process, which is mediated by the coordinated function of specialized …

SARS-CoV-2 infection and mRNA vaccination induce robust CD4+ T cell responses that are
critical for the development of protective immunity. Here, we evaluated spike-specific CD4+ …