A new era in the science and care of kidney diseases
Notable progress in basic, translational and clinical nephrology research has been made
over the past five decades. Nonetheless, many challenges remain, including obstacles to …
over the past five decades. Nonetheless, many challenges remain, including obstacles to …
[HTML][HTML] Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
J Pell, S Nagata, MC Menon - Kidney360, 2023 - journals.lww.com
Since the seminal discovery of the trypanolytic, exonic variants in apolipoprotein L1 (APOL1)
and their association with kidney disease in individuals of recent African ancestry, a wide …
and their association with kidney disease in individuals of recent African ancestry, a wide …
Phenotypes of APOL1 high-risk status subjects
In this issue of the JASN, Elliott and colleagues report the clinical characteristics of 239
patients harboring two apolipoprotein L1 (APOL1) kidney risk alleles, perhaps the largest …
patients harboring two apolipoprotein L1 (APOL1) kidney risk alleles, perhaps the largest …
[HTML][HTML] Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study
H Trachtman, J Radhakrishnan, MN Rheault… - Kidney International …, 2024 - Elsevier
Introduction The phase 3 DUPLEX trial is evaluating sparsentan, a novel,
nonimmunosuppressive, single-molecule dual endothelin angiotensin receptor antagonist …
nonimmunosuppressive, single-molecule dual endothelin angiotensin receptor antagonist …
Integrating Genetic Ancestry into Clinical Care: Accuracy, Utility, and Stakeholder Views
JS Prettyman, TJ Hoffmann, S Biswas, A Rajkovic - medRxiv, 2024 - medrxiv.org
PURPOSE: This study aimed to evaluate the concordance of genetic ancestry reports from
different providers, assess the accuracy of genetic ancestry compared to self-identified race …
different providers, assess the accuracy of genetic ancestry compared to self-identified race …
[HTML][HTML] Higher prevalence of kidney function impairment among older people living with HIV in Uganda
AJ Ssemasaazi, R Kalyesubula, YC Manabe… - Research …, 2024 - ncbi.nlm.nih.gov
Background People living with HIV (PLWH) are at risk of kidney function impairment due to
HIV-related inflammation, antiretroviral therapy (ART), diabetes mellitus, and hypertension …
HIV-related inflammation, antiretroviral therapy (ART), diabetes mellitus, and hypertension …
Prevalence of Mendelian kidney disease among patients with high-risk APOL1 genotypes undergoing commercial genetic testing in the United States
RS Francisco Jr, S Punj, L Vincent, N Sanapareddy… - medRxiv, 2024 - medrxiv.org
Background: Among individuals with high-risk APOL1 genotypes, the lifetime risk of
developing kidney failure is~ 15%, indicating that other genetic variants or non-genetic …
developing kidney failure is~ 15%, indicating that other genetic variants or non-genetic …
[HTML][HTML] Prevalence of Mendelian kidney disease among patients with high-risk APOL1 genotypes undergoing commercial genetic testing in the United States
R da Silva Francisco Jr, S Punj, L Vincent… - Kidney International …, 2024 - Elsevier
Introduction Among individuals with high-risk APOL1 genotypes, the lifetime risk of
developing kidney failure is∼ 15%, indicating that other genetic variants or non-genetic …
developing kidney failure is∼ 15%, indicating that other genetic variants or non-genetic …
[PDF][PDF] Who is eligible?
S Wilson - labcorpapol1test.com
APOL1 Genotyping Program Page 1 Patient is of African ancestry including those who self-identify
as Black, African American, African or Afro-Caribbean. Patient has a diagnosis of non-diabetic …
as Black, African American, African or Afro-Caribbean. Patient has a diagnosis of non-diabetic …