Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update

C Chakraborty, AR Sharma, G Sharma… - Journal of advanced …, 2021 - Elsevier
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

Circular RNA: a new biomarker for different types of hypertension

D Sekar - Hypertension Research, 2019 - nature.com
In developing and developed countries, hypertension (HTN) is one of the most common,
complex non-communicable diseases, and it is caused by many factors, including genetic …

Non-coding RNAs in rheumatoid arthritis: from bench to bedside

J Wang, S Yan, J Yang, H Lu, D Xu… - Frontiers in immunology, 2020 - frontiersin.org
Rheumatoid arthritis is a common systemic and autoimmune disease characterized by
symmetrical and inflammatory destruction of distal joints. Its primary pathological characters …

Roles of microRNA-122 in cardiovascular fibrosis and related diseases

Y Liu, JW Song, JY Lin, R Miao, JC Zhong - Cardiovascular Toxicology, 2020 - Springer
Fibrotic diseases cause annually more than 800,000 deaths worldwide, where of the
majority accounts for cardiovascular fibrosis, which is characterized by endothelial …

Endothelial dysfunction in diabetes and hypertension: role of microRNAs and long non-coding RNAs

H Zhang, Q Xu, A Thakur, MO Alfred, M Chakraborty… - Life sciences, 2018 - Elsevier
The vascular endothelium acts as a barrier between the blood flow and the inner lining of
the vessel wall, and it functions as a filtering machinery to filter out any unwanted transfer of …

Noncoding RNAs in hypertension

A Jusic, Y Devaux… - …, 2019 - Am Heart Assoc
High blood pressure or hypertension is an outstanding public health problem affecting
nearly 40% of the World's adult population. Prevalence of hypertension has a strong …

The current state of MiRNAs as biomarkers and therapeutic tools

I Gareev, O Beylerli, G Yang, J Sun, V Pavlov… - Clinical and …, 2020 - Springer
MicroRNAs (miRNAs) are non-coding RNAs with a length of 18–22 nucleotides that regulate
about a third of the human genome at the post-transcriptional level. MiRNAs are involved in …

The emerging role of MicroRNAs in bone diseases and their therapeutic potential

LA Bravo Vázquez, MY Moreno Becerril… - Molecules, 2021 - mdpi.com
MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-
coding RNA molecules whose main function is the post-transcriptional regulation of gene …

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

Y Zhao, Z Wang, W Zhang, L Zhang - Biofactors, 2019 - Wiley Online Library
Autophagy is a highly conserved catabolic process and fundamental biological process in
eukaryotic cells. It recycles intracellular components to provide nutrients during starvation …