Abstract Purpose: The AKT/PKB kinase controls many of the intracellular processes that are
dysregulated in human cancer, including the suppression of apoptosis and anoikis and the …

The antiproliferative action of 2-methoxyestradiol (2-ME), an endogenous estrogen
metabolite is specific for cancer cells and is mediated by the induction of programmed cell …

We have shown previously that the pathways leading to Fas-mediated apoptosis in prostatic
carcinoma cell lines are intact, because apoptosis can be triggered either by Fas ligation …

Apoptosis is an integral part of normal mammary gland development, differentiation, and
function. Numerous descriptive and mechanistic studies of programmed cell death pathways …

Because of the complex and multifaceted nature of cancer cell metabolism, a better
understanding of the metabolism of cancer cells and the factors that control its expression …

Prostate cancer is the most commonly diagnosed nonskin malignancy in American men,
with an estimated 184,000 new cases projected for 2000 (8). It will be responsible for more …

Apoptosis is a process critical to tissue homeostasis. The term describes a series of
morphological changes that result in selective cell removal, but does not instigate a general …

Quisiera expresar mi más sincero agradecimiento a la Profesora Dª. Antonia Aránega
Jiménez y al Profesor D. Luis Álvarez Guisado, por el cariño con que me acogieron en este …

DAL-1, a new member in the NF2/ERM14. 1 superfamily, is lost in greater than 60% of
primary breast tumors and decreases growth in MCF-7 breast cancer cells. The mechanism …

TESIS DOCTORAL Octavio Caba Pérez Granada, 2006 Page 1 TESIS DOCTORAL
POTENCIAL TERAPÉUTICO DE NUEVOS FÁRMACOS ANTITUMORALES. ESTUDIO SOBRE …