Recent investigations have demonstrated the need for a precise differentiation of various
forms of cell death such as apoptosis, oncosis, necrosis and programmed cell death …

Monoclonal antibodies (mAbs) are currently used for many diagnostic and therapeutic
applications. The high demand for these biopharmaceuticals has led to the development of …

Garlic (Allium sativum) has been used for centuries for treating various ailments, and its
consumption is said to reduce cancer risk and its extracts and components effectively block …

A family of cysteine proteases, the caspases, plays a central role in the initiation and
execution phases of apoptosis. Upon activation, these enzymes cleave specific substrates …

The caspase-3 zymogen has essentially zero activity until it is cleaved by initiator caspases
during apoptosis. However, a mutation of V266E in the dimer interface activates the …

Azurin, a copper-containing redox protein released by the pathogenic bacterium
Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7 …

Caspase-3 is an important proteolytic enzyme that cleaves several key substrates in
apoptotic processes, resulting in DNA fragmentation, the degradation of nuclear proteins …

Sodium butyrate (NaBu) can enhance the expression of genes controlled by some of the
mammalian promoters, but it can also inhibit cell growth and induce cellular apoptosis. Thus …

Recombinant glycoprotein therapeutics have proven to be invaluable pharmaceuticals for
the treatment of various diseases. Chinese hamster ovary (CHO) cells are widely used in …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …