Background Bronchiectasis revealed by chest computed tomography in COPD patients and
its comorbid effect on prognosis have not been addressed by large-sized studies …

Background Exacerbations of chronic obstructive pulmonary disease (COPD) are a major
driver of decline in health status and impose high costs on healthcare systems. Action plans …

Rationale: The small conducting airways are the major site of airflow obstruction in chronic
obstructive pulmonary disease and may precede emphysema development. Objectives: We …

OBJECTIVE: To examine the prevalence and magnitude of chronic lung disease (CLD) and
its association with empiric anti-tuberculosis treatment (due to lack of bacteriologic …

Background Emphysema has considerable variability in its regional distribution.
Craniocaudal emphysema distribution is an important predictor of the response to lung …

Background: Little is known about factors associated with emphysema progression in
cigarette smokers. We evaluated factors associated with change in emphysema and forced …

Background Traditional metrics of lung disease such as those derived from spirometry and
static single-volume CT images are used to explain respiratory morbidity in patients with …

Rationale: Quantitative computed tomography (CT) has been used to phenotype patients
with chronic obstructive pulmonary disease (COPD). A mixed phenotype is defined as the …

Rationale and Objectives Many patients with chronic obstructive pulmonary disease (COPD)
have marked discordance between forced expiratory volume in 1 second (FEV 1) and …

Objective The presence of both emphysema and airway wall thickening determined via
volumetric computed tomography (CT) is defined as mixed phenotype. The long-term clinical …