BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Female fecundity declines in a nonlinear manner with age during the reproductive years,
even as ovulatory cycles continue, which reduces female fertility, disrupts metabolic …

Macrophages (MΦs) are the most abundant leukocytes in mammalian ovaries that have
heterogeneity and plasticity. A body of evidence has indicated that these cells are important …

The decline in fertility in aging women, especially those with poor ovarian response (POR)
or primary ovarian insufficiency (POI), is a major concern for modern IVF centers. Fertility …

The ovary is a female reproductive organ that plays a key role in fertility and the
maintenance of endocrine homeostasis, which is of great importance to women's health. It is …

Background In the modern sheep production systems, the reproductive performance of ewes
determines the economic profitability of farming. Revealing the genetic mechanisms …

With the increase in the age of laying chickens, the aging of follicles is accelerated, and the
reproductive ability is decreased. Increased oxidative stress and mitochondrial malfunction …

Endocrine-disrupting chemicals (EDCs) dysregulate hormone metabolism via interfering
with estrogen, thyroid, and nuclear receptors such as peroxisome proliferator-activated …