HIV latency
RF Siliciano, WC Greene - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
Dissecting how CD4 T cells are lost during HIV infection
Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail,
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …
Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells
J Hasselmann, M Blurton‐Jones - Glia, 2020 - Wiley Online Library
Recent advances in the generation of microglia from human induced pluripotent stem cells
(iPSCs) have provided exciting new approaches to examine and decipher the biology of …
(iPSCs) have provided exciting new approaches to examine and decipher the biology of …
HIV pathogenesis: dynamics and genetics of viral populations and infected cells
J Coffin, R Swanstrom - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
In the absence of treatment, HIV-1 infection, usually starting with a single virion, leads
inexorably to a catastrophic decline in the numbers of CD4+ T cells and to AIDS …
inexorably to a catastrophic decline in the numbers of CD4+ T cells and to AIDS …
Stem-cell-derived human microglia transplanted into mouse brain to study human disease
N Fattorelli, A Martinez-Muriana, L Wolfs, I Geric… - Nature protocols, 2021 - nature.com
Microglia are critically involved in complex neurological disorders with a strong genetic
component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia …
component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia …
Single-cell characterization of viral translation-competent reservoirs in HIV-infected individuals
HIV cure efforts are hampered by limited characterization of the cells supporting HIV
replication in vivo and inadequate methods for quantifying the latent viral reservoir in …
replication in vivo and inadequate methods for quantifying the latent viral reservoir in …
Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation
Objective and design: Though combination antiretroviral therapy reduces the concentration
of HIV-1 RNA in both plasma and cerebrospinal fluid (CSF) below the detection limit of …
of HIV-1 RNA in both plasma and cerebrospinal fluid (CSF) below the detection limit of …
[HTML][HTML] Recent insights into the HIV/AIDS pandemic
JC Becerra, LS Bildstein, JS Gach - Microbial cell, 2016 - ncbi.nlm.nih.gov
Etiology, transmission and protection: Transmission of HIV, the causative agent of AIDS,
occurs predominantly through bodily fluids. Factors that significantly alter the risk of HIV …
occurs predominantly through bodily fluids. Factors that significantly alter the risk of HIV …
Are microRNAs important players in HIV-1 infection? An update
M Balasubramaniam, J Pandhare, C Dash - Viruses, 2018 - mdpi.com
HIV-1 has already claimed over 35 million human lives globally. No curative treatments are
currently available, and the only treatment option for over 36 million people currently living …
currently available, and the only treatment option for over 36 million people currently living …
Co-Infection and Cancer: Host–Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses
Dendritic cells (DCs) function as a link between innate and adaptive immune responses.
Retroviruses HIV-1 and HTLV-1 modulate DCs to their advantage and utilize them to …
Retroviruses HIV-1 and HTLV-1 modulate DCs to their advantage and utilize them to …