Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell
commitment to the male pathway and are essential for germ cell development, from …

Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We
aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

The testis produces sperm throughout the male reproductive lifespan by balancing self-
renewal and differentiation of spermatogonial stem cells (SSCs). Part of the SSC niche is …

The requirement for vitamin A in reproduction was first recognized in the early 1900's, and its
importance in the eyes of developing embryos was realized shortly after. A greater …

In mammals, meiosis is initiated at different time points in males and females, but the
mechanism underlying this difference is unknown. Female germ cells begin meiosis during …

Retinoic acid (RA), the active form of vitamin A, is a small lipophilic molecule that acts as a
signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA …

Spermiation is the process by which mature spermatids are released from Sertoli cells into
the seminiferous tubule lumen prior to their passage to the epididymis. It takes place over …