Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis, emphysema,
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …

IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …

Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …

Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …

The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …

Cystic fibrosis is a multiorgan disease caused by impaired function of the cystic fibrosis
transmembrane conductance regulator (CFTR). Since the introduction of the CFTR …

The human lung cellular portfolio, traditionally characterized by cellular morphology and
individual markers, is highly diverse, with over 40 cell types and a complex branching …

Rationale: Remodeling and loss of distal conducting airways, including preterminal and
terminal bronchioles (pre-TBs/TBs), underlie progressive airflow limitation in chronic …

Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal
surface of microvessels, where they provide structural and biochemical support. Pericytes …

Adult lung resident stem/progenitor cells, including P63+ progenitor cells, have
demonstrated the capacity for regeneration of lung epithelium in preclinical models. Here …