Epithelial cells are charged with protection at barrier sites, but whether this normally
beneficial response might sometimes become dysfunctional still needs definition. Here, we …

Basal cells are multipotent stem cells of a variety of organs, including the respiratory tract,
where they are major components of the airway epithelium. However, it remains unclear …

Abstract N6‐methyladenosine (m6A) RNA methylation, the most prevalent internal chemical
modification of mRNA, has been reported to participate in the progression of various …

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths
worldwide. Although advances are being made towards earlier detection and the …

Abnormalities in airway mucus lead to chronic disorders in the pulmonary system such as
asthma, fibrosis and chronic obstructive pulmonary disease (COPD). Among these, COPD is …

Club cells are found in human small airways where they play an important role in immune
defense, xenobiotic metabolism, and repair after injury. Over the past few years, data from …

Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and
regeneration. This requires significant proliferative potential ensured by sufficient telomere …

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …

Extracellular matrix (ECM) assembly/disassembly is a critical regulator for airway epithelial
development and remodeling. Airway organoid is widely used in respiratory research, yet …

Chronic obstructive pulmonary disease (COPD) is a complex and serious disease that is
characterized by dyspnea, fatigue, decreased exercise tolerance, peripheral muscle …