The TP63 is an indispensable transcription factor for development and homeostasis of
epithelia and its derived glandular tissue. It is also involved in female germline cell quality …

Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage
labeling have yielded identification of multiple abnormal epithelial progenitor populations …

Genetic information is not transmitted solely by DNA but by the epigenetics process.
Epigenetics describes molecular missing link pathways that could bridge the gap between …

Although a few studies show that the use of electronic nicotine delivery systems (ENDS) may
ameliorate objective and subjective outcomes in COPD smokers who switched to electronic …

Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of
human death globally. Enhanced chronic inflammation and pathological remodeling are the …

The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …

Background In cystic fibrosis, the respiratory epithelium is the target tissue of both the
genetic abnormality of the disease and of external aggressions, notably by pathogens …

Lung diseases disproportionately affect elderly individuals. The lungs form a unique
environment: a highly elastic organ with gaseous exchange requiring the closest proximity of …

Background An intergenic region at chromosome 4q31 is one of the most significant regions
associated with COPD susceptibility and lung function in GWAS. In this region, the …

Neutrophilic inflammation results in loss of lung function in chronic obstructive pulmonary
disease (COPD). Gram-negative bacteria, such as nontypeable Haemophilus influenzae …