Cpt1a alleviates cigarette smoke‑induced chronic obstructive pulmonary disease

L Li, Y Zhang, J Gong, G Yang… - Experimental and …, 2022 - spandidos-publications.com
The current study aimed to determine the expression of carnitine palmitoyltransferase 1A
(Cpt1a) in the lung tissue of chronic obstructive pulmonary disease (COPD) patients and its …

[HTML][HTML] Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

SL Brody, J Pan, T Huang, J Xu, H Xu, J Koenitizer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Motile cilia have essential cellular functions in development, reproduction, and homeostasis.
Genetic causes for motile ciliopathies have been identified, but the consequences on …

Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4‐ankyrin repeat domain

L Niu, Y Lu, X Zu, W Yang, F Shen, Y Xu… - Phytotherapy …, 2023 - Wiley Online Library
Transient receptor potential vanilloid 4 (TRPV4) plays a role in regulating pulmonary fibrosis
(PF). While several TRPV4 antagonists including magnolol (MAG), have been discovered …

Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary …

H Qi, H Liu, SS Pullamsetti, S Günther, C Kuenne… - Circulation, 2021 - Am Heart Assoc
Background: The pathogenesis of life-threatening cardiopulmonary diseases such as
pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD) originates …

[HTML][HTML] Repairing damaged lungs using regenerative therapy

PPPSJ Khedoe, X Wu, R Gosens… - Current Opinion in …, 2021 - Elsevier
There is an urgent need for better treatment of lung diseases that are a major cause of
morbidity and mortality worldwide. This urgency is illustrated by the current COVID-19 health …

Preclinical studies and the function of IL-17 cytokines in COPD

F Ritzmann, C Beisswenger - Annals of Anatomy-Anatomischer Anzeiger, 2021 - Elsevier
Chronic obstructive pulmonary disease (COPD) is among the leading causes of death
worldwide and imposes a high economic burden to the health systems. COPD is …

Pulmonary embolism induces pneumonia‐like lung injury beyond pulmonary infarction

Y Wang, B Liu, C Zhou, Y Wang, J Miao… - Pulmonary …, 2023 - Wiley Online Library
Patients with pulmonary embolism (PE) commonly manifest concomitant “pneumonia,”
which is generally believed to be either a cause (infection) or a consequence (infarction) of …

[HTML][HTML] The efficacy and safety of combined traditional Chinese and western medicine in the treatment of chronic obstructive pulmonary disease complicated with …

P Huang, X Lin, Y Liu, Z Hou - Annals of Palliative Medicine, 2022 - apm.amegroups.org
Background: The conventional drugs to treat chronic obstructive pulmonary disease (COPD)
complicated with respiratory failure (RF)(COPD+ RF) in western medicine include …

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β‐catenin activator inducing lung epithelial organoid formation

R Costa, DE Wagner, A Doryab… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Emphysema is an incurable disease characterized by loss of lung
tissue leading to impaired gas exchange. Wnt/β‐catenin signalling is reduced in …

Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts‐induced BEAS‐2B cells by modulating MMP‐9/TIMP‐1 signaling

W Xu, F Li, L Zhu, M Cheng… - Journal of Biochemical …, 2023 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality. Here, we
aimed to explore the roles and potential correlation of placenta polypeptide injection (PPI) …