Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro

TP Dale, MD Santer, M Haris, W Zuo… - ExpErimEntal lung …, 2023 - Taylor & Francis
Purpose Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia
and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale …

Stem cell–derived respiratory epithelial cell cultures as human disease models

JC Orr, RE Hynds - American Journal of Respiratory Cell and …, 2021 - atsjournals.org
Advances in stem cell biology and the understanding of factors that determine lung stem cell
self-renewal have enabled long-term in vitro culture of human lung cells derived from airway …

Prediction models for pulmonary function during acute exacerbation of chronic obstructive pulmonary disease

J Chen, Z Yang, Q Yuan, D Xiong… - Physiological …, 2020 - iopscience.iop.org
Objective: The pulmonary function test is an effort-dependent test; however, during acute
exacerbation of chronic obstructive pulmonary disease (AECOPD), patients are unable to …

[Retracted] Clinical Observation of General Anesthesia Combined with Spinal Anesthesia in Elderly Patients with Chronic Obstructive Pulmonary Disease

J Chen, J Wang, X Duan, F Ping… - BioMed Research …, 2022 - Wiley Online Library
Objective. This work is aimed at evaluating the efficacy and safety of general anesthesia
(GA) combined with spinal anesthesia (SA)(GA+ SA) in elderly patients with chronic …

Airway basal cells in chronic obstructive pulmonary disease: a continuum or a dead end?

R Shaykhiev - American journal of respiratory cell and molecular …, 2021 - atsjournals.org
Progressive airflow limitation in chronic obstructive pulmonary disease (COPD) develops
because of stable changes in airway structure known as airway remodeling. Common …

基于机器学习的慢性阻塞性肺疾病急性加重预测模型的研究

张博超, 杨朝, 郭立泉, 陈静, 熊大曦 - 中国康复理论与实践, 2022 - cjrtponline.com
目的针对慢性阻塞性肺疾病急性加重期(AECOPD) 患者肺功能检测存在误差大,
准确性差的问题, 开发AECOPD 患者的肺功能预测模型, 通过比较不同机器学习模型的预测性能 …

[HTML][HTML] World Lung Day: what, why, and where to?

KM Fong, T Welte - American Journal of Physiology-Lung …, 2020 - journals.physiology.org
The idea of World Lung Day (WLD) was first conceived at the 2016 FIRS Kyoto Assembly
meeting hosted by then FIRS President Michiaki Mishima. FIRS recognized the need for …

Cystic Fibrosis Airways: Does Disease Stem from Faulty Stem Cells?

KB Hisert, EK Vladar - American Journal of Respiratory and Critical …, 2023 - atsjournals.org
The last decade has seen remarkable breakthrough therapies for several genetic diseases
including cystic fibrosis (CF)(1, 2). CF results when an individual possesses two mutant …

[HTML][HTML] Airway epithelium regeneration by photoactivated basal cells

S Wang, S Shan, J Zhang, Z Liu, X Gu, Y Hong… - … of Photochemistry and …, 2023 - Elsevier
The airway epithelium is the footstone to maintain the structure and functions of lung, in
which resident basal cells (BCs) maintain homeostasis and functional regeneration of …

Investigation of molecular mechanisms underlying immunological and respiratory disorders using single-cell RNA sequencing

CT Wohnhaas - 2022 - kops.uni-konstanz.de
Respiratory diseases are a leading cause of disability and death worldwide. Several of the
most prevalent respiratory diseases are associated with smoking, including chronic …