The immune system is capable of recognizing tumors and eliminates many early malignant
cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is …

Autoimmune reactions reflect an imbalance between effector and regulatory immune
responses, typically develop through stages of initiation and propagation, and often show …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

The mechanism of action of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) remains
surprisingly unclear. Regulatory T (Treg) cells can use CTLA-4 to elicit suppression; …

After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have
gained a detailed knowledge of the cells involved, specific recognition mechanisms and …

Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …

Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like
anchor protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

PURPOSE The risk of immune checkpoint inhibitor therapy–related GI adverse events in
patients with cancer and inflammatory bowel disease (IBD) has not been well described. We …