Background LPS-responsive beige-like anchor (LRBA) deficiency presents with
susceptibility to infections, autoimmunity, and lymphoproliferation. The long-term efficacy of …

Autoimmunity and immunodeficiency were previously considered to be mutually exclusive
conditions; however, increased understanding of the complex immune regulatory and …

Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding
how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and …

Aim The growing use of immune checkpoint inhibitors (ICIs) is associated with the
occurrence of immune-related adverse events (irAEs). Few data are published on systemic …

Tregs have a role in immunological tolerance and immune homeostasis by suppressing
immune reactions, and its therapeutic potential is critical in autoimmune diseases and …

Common variable immunodeficiency (CVID), characterized by recurrent infections, is the
most prevalent symptomatic antibody deficiency. In∼ 90% of CVID-affected individuals, no …

To date, several germline mutations have been identified in the LRBA gene in patients
suffering from a variety of clinical symptoms. These mutations abolish the expression of the …

Monogenic diseases of the immune system, also known as inborn errors of immunity, are
caused by single-gene mutations resulting in immune deficiency and dysregulation. More …

CTLA-4 is a critical negative regulator of the immune system and a major target for
immunotherapy. However, precisely how it functions in vivo to maintain immune …

Susceptibility to multiple autoimmune diseases is associated with common gene
polymorphisms influencing IL-2 signaling and T reg function, making T reg-specific …