The response of peripheral T lymphocytes (T cell) is controlled by multiple checkpoints to
avoid unwanted activation against self-tissues. Two opposing costimulatory receptors, CD28 …

Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised
by hypogammaglobulinaemia, impaired production of specific antibodies after immunisation …

Evans syndrome (ES) is a rare severe autoimmune disorder characterized by the
combination of autoimmune hemolytic anemia and immune thrombocytopenia. In most …

Abstract CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity,
balancing the activation and inhibition of T cell responses, respectively. Although both …

Recent advances in the development of sequencing technologies provide researchers with
unprecedented possibilities for genetic analyses. In this review, we will discuss the history of …

A proportion of people living with common variable immunodeficiency disorders develop
granulomatous-lymphocytic interstitial lung disease (GLILD). We aimed to develop a …

Background Recent findings strongly support hematopoietic stem cell transplantation
(HSCT) in patients with severe presentation of LPS-responsive beige-like anchor protein …

Gene regulatory networks ensure that important genes are expressed at precise levels.
When gene expression is sufficiently perturbed, it can lead to disease. To understand how …

T-cell mediated immune responses should be regulated to avoid the development of
autoimmune or chronic inflammatory diseases. Several mechanisms have been described …

Primary immune regulatory disorders (PIRD) are associated with autoimmunity,
autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune …