We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Objective—Cardiovascular disease (CVD), the most common morbidity resulting from
atherosclerosis, remains a frequent cause of death. Efforts to develop effective therapeutic …

VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels
from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of …

Interfering with interactions of vascular endothelial growth factors (VEGFs) with their
receptors (VEGFRs) effectively inhibits angiogenesis and tumor growth. We designed an …

Impairment of sphincter muscles or their neural and vascular support leads to stress urinary
incontinence. The aim of this study was to determine the role of urine-derived stem cells …

Although graphene oxide (GO) has recently been considered as a highly attractive
nanomaterial for future cancer imaging and therapy, it is still a major challenge to improve its …

Angiogenesis is an essential neovascularisation process, which if recapitulated in 3D in
vitro, will provide better understanding of endothelial cell (EC) behaviour. Various cell types …

VEGF receptor (VEGFR) cell surface localization plays a critical role in transducing VEGF
signaling toward angiogenic outcomes, and quantitative characterization of these …

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis.
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …

Dysregulation of tyrosine kinase receptor (RTK) signaling pathways play important roles in
glioblastoma (GBM). However, therapies targeting these signaling pathways have not been …