Nuclear morphologies: their diversity and functional relevance

BM Skinner, EEP Johnson - Chromosoma, 2017 - Springer
Studies of chromosome and genome biology often focus on condensed chromatin in the
form of chromosomes and neglect the non-dividing cells. Even when interphase nuclei are …

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling

JL Decano, Y Iwamoto, S Goto, JY Lee, JT Matamalas… - Cell reports, 2022 - cell.com
Cellular heterogeneity of aortic valves complicates the mechanistic evaluation of the
calcification processes in calcific aortic valve disease (CAVD), and animal disease models …

[HTML][HTML] Arterial calcification: finger-pointing at resident and circulating stem cells

F Vasuri, S Fittipaldi, G Pasquinelli - World journal of stem cells, 2014 - ncbi.nlm.nih.gov
Abstract The term ''Stammzelle''(stem cells) originally appeared in 1868 in the works of Ernst
Haeckel who used it to describe the ancestor unicellular organism from which he presumed …

Metakaryotic stem cell nuclei use pangenomic dsRNA/DNA intermediates in genome replication and segregation

WG Thilly, EV Gostjeva, VV Koledova… - …, 2014 - Taylor & Francis
Bell shaped nuclei of metakaryotic cells double their DNA content during and after
symmetric and asymmetric amitotic fissions rather than in the separate, pre-mitotic S-phase …

Human fetal/tumor metakaryotic stem cells: pangenomic homologous pairing and telomeric end-joining of chromatids

AN Gruhl, EV Gostjeva, WG Thilly, JN Fomina… - Cancer genetics and …, 2010 - Elsevier
Metakaryotic cells and syncytia with large, hollow, bell-shaped nuclei demonstrate
symmetrical and asymmetrical amitotic nuclear fissions in microanatomical positions and …

[PDF][PDF] Metakaryotic cells linked to pediatric pulmonary vein stenosis

EC Kirkpatrick, ME Mitchell, WG Thilly… - Cardiovasc …, 2019 - academia.edu
1. Methods Pulmonary vein tissue from five patients with PVS was collected at the time of
surgical intervention. The tissue was fixed in Carnoy solution within 30 min of removal from …

The study of calcified atherosclerotic arteries: an alternative to evaluate the composition of a problematic tissue reveals new insight including metakaryotic cells

S Fittipaldi, F Vasuri, A Degiovanni, R Pini… - BMC Clinical …, 2016 - Springer
Background Calcifications of atherosclerotic plaques represent a controversial issue as they
either lead to the stabilization or rupture of the lesion. However, the cellular key players …

Mutator/hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis

LG Kini, P Herrero-Jimenez, T Kamath… - Frontiers in …, 2013 - frontiersin.org
Adult age-specific colorectal cancer incidence rates increase exponentially from maturity,
reach a maximum, then decline in extreme old age. Armitage and Doll postulated that the …

Metakaryotic cancer stem cells are constitutively resistant to X-rays and chemotherapeutic agents, but sensitive to many common drugs

EV Gostjeva, VV Koledova, L Bai, KC Duan, T Kamath… - 2016 - books.rsc.org
Metakaryotic Cancer Stem Cells are Constitutively Resistant to X-Rays and
Chemotherapeutic Agents, but Sensitive to Many Common Drugs | Human Stem Cell …

Methods for identifying stem cells based on nuclear morphotypes

EV Gostjeva, WG Thilly - US Patent 8,465,943, 2013 - Google Patents
US8465943B2 - Methods for identifying stem cells based on nuclear morphotypes - Google
Patents US8465943B2 - Methods for identifying stem cells based on nuclear morphotypes …