Nucleoid-associated proteins (NAPs) play a central role in chromosome organization and
environment-responsive transcription regulation. The Bacillus subtilis-encoded NAP Rok …

In archaea, histones play a role in genome compaction and are involved in transcription
regulation. Whereas archaeal histones bind DNA without sequence specificity, they bind …

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B
that assemble into octameric nucleosome particles. Archaeal histones are dimeric and …

Many archaea express histones, which organize the genome and play a key role in gene
regulation. The structure and function of archaeal histone–DNA complexes remain however …

DNA mismatch repair (MMR) corrects errors that occur during DNA replication. In humans,
mutations in the proteins MutSα and MutLα that initiate MMR cause Lynch syndrome, the …

DNA looping is important for genome organization in all domains of life. The basis of DNA
loop formation is the bridging of two separate DNA double helices. Detecting DNA bridge …

Many single-molecule biophysical techniques rely on nanometric tracking of microbeads to
obtain quantitative information about the mechanical properties of biomolecules such as …

Bacterial chromosome structure is, to a great extent, organized by a diverse group of
proteins collectively referred to as nucleoid-associated proteins (NAPs). Many NAPs have …

Rok from Bacillus subtilis is an abundant DNA binding protein similar in function to H-NS-
like proteins found in many proteobacteria. Rok binds across the genome with a preference …

Abstract DNA Mismatch Repair (MMR) is a universally conserved system that recognizes
errors made during the replication process, such as base-base mismatches and insertions …