TGF-β signaling and resistance to cancer therapy

M Zhang, YY Zhang, Y Chen, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …

TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy

M Yi, T Li, M Niu, Y Wu, Z Zhao, K Wu - Frontiers in Immunology, 2022 - frontiersin.org
Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes,
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …

Oral nanotherapeutics of andrographolide/carbon monoxide donor for synergistically anti-inflammatory and pro-resolving treatment of ulcerative colitis

Y Zhou, M Yang, X Yan, L Zhang, N Lu… - … Applied Materials & …, 2023 - ACS Publications
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology affecting
the colon and rectum. Current therapeutics are focused on suppressing inflammation but are …

Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy

T Li, X Wang, M Niu, M Wang, J Zhou, K Wu… - Frontiers in …, 2023 - frontiersin.org
The PD-1/PD-L1 signaling pathway plays a crucial role in cancer immune evasion, and the
use of anti-PD-1/PD-L1 antibodies represents a significant milestone in cancer …

Role of transforming growth factor-β1 in regulating fetal-maternal immune tolerance in normal and pathological pregnancy

D Yang, F Dai, M Yuan, Y Zheng, S Liu… - Frontiers in …, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …

Crossed pathways for radiation-induced and immunotherapy-related lung injury

Z Zhang, J Zhou, V Verma, X Liu, M Wu, J Yu… - Frontiers in …, 2021 - frontiersin.org
Radiation-induced lung injury (RILI) is a form of radiation damage to normal lung tissue
caused by radiotherapy (RT) for thoracic cancers, which is most commonly comprised of …

Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

W Xu, W Liu, J Yang, J Lu, H Zhang… - Immunological …, 2024 - Wiley Online Library
Immunogenic cell death (ICD) is a special pattern of tumor cell death, enabling to elicit tumor‐
specific immune response via the release of damage‐associated molecular patterns and …

A review on targeting tumor microenvironment: The main paradigm shift in the mAb-based immunotherapy of solid tumors

A Aghanejad, SF Bonab, M Sepehri… - International journal of …, 2022 - Elsevier
Monoclonal antibodies (mAbs) as biological macromolecules have been remarked the large
and growing pipline of the pharmaceutical market and also the most promising tool in …

Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis

Z Liu, L Zhang, Y Liang, L Lu - Frontiers in cellular and infection …, 2022 - frontiersin.org
Schistosomiasis has been widely disseminated around the world, and poses a significant
threat to human health. Schistosoma eggs and soluble egg antigen (SEA) mediated …

MFSD2A potentiates gastric cancer response to anti‐PD‐1 immunotherapy by reprogramming the tumor microenvironment to activate T cell response

B Zhang, CM Wang, HX Wu, F Wang… - Cancer …, 2023 - Wiley Online Library
Background The efficacy of anti‐programmed cell death protein 1 (PD‐1) immunotherapy in
various cancers, including gastric cancer (GC), needs to be potentiated by more effective …