Novel therapeutic approaches for Alzheimer's disease: an updated review
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline
Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …
human health. Several preclinical studies have been conducted to provide a rationale for …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Curcumin interacts with α-synuclein condensates to inhibit amyloid aggregation under phase separation
B Xu, J Chen, Y Liu - ACS omega, 2022 - ACS Publications
The amyloid aggregation of α-synuclein (α-Syn) is highly associated with Parkinson's
disease (PD). Discovering α-Syn amyloid inhibitors is one of the strategies for PD therapies …
disease (PD). Discovering α-Syn amyloid inhibitors is one of the strategies for PD therapies …
Neuroprotective Effect of NO-Delivery Dinitrosyl Iron Complexes (DNICs) on Amyloid Pathology in the Alzheimer's Disease Cell Model
WH Chuang, YT Chou, YH Chen, TH Kuo… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
impairment, memory loss, and behavioral deficits. β-amyloid1–42 (Aβ1–42) aggregation is a …
impairment, memory loss, and behavioral deficits. β-amyloid1–42 (Aβ1–42) aggregation is a …
A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action
S La Manna, C Di Natale, V Panzetta, M Leone… - Inorganic …, 2023 - ACS Publications
The physical and chemical properties of paddlewheel diruthenium compounds are highly
dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare …
dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare …
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
J Wu, X Kou, H Ju, H Zhang, A Yang, R Shen - Bioorganic & Medicinal …, 2021 - Elsevier
A series of naringenin derivatives were designed and synthesized as multifunctional anti-
Alzheimer's disease (AD) agents. The results showed that these derivatives displayed …
Alzheimer's disease (AD) agents. The results showed that these derivatives displayed …
Myricetin inhibits α‐synuclein amyloid aggregation by delaying the liquid‐to‐solid phase transition
B Xu, X Mo, J Chen, H Yu, Y Liu - Chembiochem, 2022 - Wiley Online Library
The aggregation of α‐synuclein (α‐Syn) is a critical pathological hallmark of Parkinson's
disease (PD). Prevention of α‐Syn aggregation has become a key strategy for treating PD …
disease (PD). Prevention of α‐Syn aggregation has become a key strategy for treating PD …
Glucosyl platinum (II) complexes inhibit aggregation of the C-terminal region of the Aβ peptide
S La Manna, M Leone, I Iacobucci… - Inorganic …, 2022 - ACS Publications
Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence,
many drug discovery processes are oriented to evaluate new compounds that are able to …
many drug discovery processes are oriented to evaluate new compounds that are able to …
Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation
Protein aggregation is responsible for various human diseases, ie Alzheimer's, Parkinson's,
Huntington's as well as cataract. Finding molecular drugs which could prevent protein …
Huntington's as well as cataract. Finding molecular drugs which could prevent protein …