Neurodegenerative diseases result in the loss of functional neurons and synapses. Although
future stem cell therapies offer some hope, current treatments for most of these diseases are …

Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …

Abstract Cyclin-dependent kinase 5 (Cdk5) and its regulatory subunit p35 are integral
players in the proper development of the mammalian central nervous system. Proteolytic …

As a progressive, irreversible neurodegenerative disease, Alzheimer's disease (AD)
continues to be a serious public health problem worldwide. Currently, the most available …

Immunizing transgenic PDAPP mice, which overexpress mutant APP and develop β‐
amyloid deposition resembling plaques in Alzheimer's disease (AD), results in a decrease of …

Introduction• Insulin, IGF‐1 in the brain• Glucose metabolism and AD• The insulin and IGF‐1
system in AD• The insulin and oxidative stress in AD• The insulin and IGF‐1R system and τ …

Postoperative cognitive dysfunction, confusion, and delirium are common after general
anesthesia in the elderly, with symptoms persisting for months or years in some patients …

There are many lines of evidence showing that oxidative stress and aberrant mitogenic
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …

Alzheimer's disease (AD) is the most common neurodegenerative disorder with
heterogeneous etiology. Intracellular neurofibrillary tangles caused by tau (τ) protein …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is accompanied by
deficits in memory and cognitive functions. The disease is pathologically characterised by …