Moxidectin: an oral treatment for human onchocerciasis

P Milton, JID Hamley, M Walker… - Expert Review of Anti …, 2020 - Taylor & Francis
Introduction Moxidectin is a milbemycin endectocide recently approved for the treatment of
human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a …

Onchocerciasis elimination: progress and challenges

T Lakwo, D Oguttu, T Ukety, R Post… - Research and Reports …, 2020 - Taylor & Francis
Onchocerciasis is a parasitic infection caused by the filarial nematode Onchocerca volvulus
and transmitted through the bites of black flies of the genus Similium that breed in rivers and …

Alternative treatment strategies to accelerate the elimination of onchocerciasis

M Boussinesq, G Fobi, AC Kuesel - International health, 2018 - academic.oup.com
The use of alternative (or complementary) treatment strategies (ATSs) ie differing from
annual community-directed treatment with ivermectin (CDTI) is required in some African foci …

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa

G Gebrezgabiher, Z Mekonnen… - Infectious diseases of …, 2019 - mednexus.org
Background: Onchocerciasis (river blindness), caused by the filarial worm species
Onchocerca volvulus, is a serious vector-borne neglected tropical disease (NTD) of public …

[HTML][HTML] Research for new drugs for elimination of onchocerciasis in Africa

AC Kuesel - International Journal for Parasitology: Drugs and Drug …, 2016 - Elsevier
Onchocerciasis is a parasitic, vector borne disease caused by the filarial nematode
Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa …

[HTML][HTML] Genomic epidemiology in filarial nematodes: transforming the basis for elimination program decisions

SM Hedtke, AC Kuesel, KE Crawford, PM Graves… - Frontiers in …, 2020 - frontiersin.org
Onchocerciasis and lymphatic filariasis are targeted for elimination, primarily using mass
drug administration at the country and community levels. Elimination of transmission is the …

[HTML][HTML] Genome-based tools for onchocerciasis elimination: Utility of the mitochondrial genome for delineating Onchocerca volvulus transmission zones

KE Crawford, SM Hedtke, SR Doyle, AC Kuesel… - International Journal for …, 2024 - Elsevier
National programs in Africa have expanded their objectives from control of onchocerciasis
(river blindness) as a public health problem to elimination of parasite transmission …

[HTML][HTML] Effect of a single dose of 8 mg moxidectin or 150 μg/kg ivermectin on O. volvulus skin microfilariae in a randomized trial: Differences between areas in the …

D Bakajika, EM Kanza, NO Opoku… - PLoS Neglected …, 2022 - journals.plos.org
Background Our study in CDTI-naïve areas in Nord Kivu and Ituri (Democratic Republic of
the Congo, DRC), Lofa County (Liberia) and Nkwanta district (Ghana) showed that a single …

[HTML][HTML] Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection

B Tan, N Opoku, SK Attah, K Awadzi… - PLOS Neglected …, 2022 - journals.plos.org
Background Onchocerciasis (“river blindness”), is a neglected tropical disease caused by
the filarial nematode Onchocerca volvulus and transmitted to humans through repeated …

Prevalence, risk factors, challenges, and the currently available diagnostic tools for the determination of helminths infections in human

M Riaz, N Aslam, R Zainab… - European Journal …, 2020 - journals.sagepub.com
Soil transmitted helminthes (STH) are among the major public health issues in tropical and
sub-tropical countries infecting more than 2 billion humans worldwide. STH causes …