A bite to fight: front-line innate immune defenses against malaria parasites
S Tannous, E Ghanem - Pathogens and global health, 2018 - Taylor & Francis
Malaria infection caused by Plasmodium parasites remains a major health burden
worldwide especially in the tropics and subtropics. Plasmodium exhibits a complex life cycle …
worldwide especially in the tropics and subtropics. Plasmodium exhibits a complex life cycle …
Plasmodium berghei-Released Factor, PbTIP, Modulates the Host Innate Immune Responses
The Plasmodium parasite has to cross various immunological barriers for successful
infection. Parasites have evolved mechanisms to evade host immune responses, which …
infection. Parasites have evolved mechanisms to evade host immune responses, which …
A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
Human Vγ9Vδ2 T Lymphocytes in the Immune Response to P. falciparum Infection
J Howard, I Zaidi, S Loizon… - Frontiers in …, 2018 - frontiersin.org
Malaria is an infectious disease caused by the protozoan parasite Plasmodium sp, the most
lethal being Plasmodium falciparum. Clinical malaria is associated with the asexual …
lethal being Plasmodium falciparum. Clinical malaria is associated with the asexual …
The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi
A Henning, SJ Clift, AL Leisewitz - Parasite immunology, 2020 - Wiley Online Library
To provide useful information based on the macropathology, histopathology and
immunohistochemical investigation in the spleens of dogs with Babesia rossi infection …
immunohistochemical investigation in the spleens of dogs with Babesia rossi infection …
Examining cellular immune responses to inform development of a blood-stage malaria vaccine
DI Stanisic, MF Good - Parasitology, 2016 - cambridge.org
Naturally acquired immunity to the blood-stage of the malaria parasite develops slowly in
areas of high endemicity, but is not sterilizing. It manifests as a reduction in parasite density …
areas of high endemicity, but is not sterilizing. It manifests as a reduction in parasite density …
In silico screening of novel inhibitors of M17 Leucine Amino Peptidase (LAP) of Plasmodium vivax as therapeutic candidate
S Rout, RK Mahapatra - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Abstract M17 LAP (Leucine Amino Peptidase) plays an important role in the hydrolysis of
amino acids essential for growth and development of Plasmodium vivax (Pv), the pathogen …
amino acids essential for growth and development of Plasmodium vivax (Pv), the pathogen …
Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria
JR Loughland, T Woodberry, MJ Boyle… - The Journal of …, 2019 - academic.oup.com
Background The malaria causing parasite Plasmodium subverts host immune responses by
several strategies including the modulation of dendritic cells (DCs). Methods In this study …
several strategies including the modulation of dendritic cells (DCs). Methods In this study …
Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria
The best correlate of malaria severity in human Plasmodium falciparum (Pf) infection is the
total parasite load. Pf-infected humans could control parasite loads by two mechanisms …
total parasite load. Pf-infected humans could control parasite loads by two mechanisms …
Systems integration of innate and adaptive immunity
DE Zak, A Aderem - Vaccine, 2015 - Elsevier
The pathogens causing AIDS, malaria, and tuberculosis have proven too complex to be
overcome by classical approaches to vaccination. The complexities of human immunology …
overcome by classical approaches to vaccination. The complexities of human immunology …