A bite to fight: front-line innate immune defenses against malaria parasites

S Tannous, E Ghanem - Pathogens and global health, 2018 - Taylor & Francis
Malaria infection caused by Plasmodium parasites remains a major health burden
worldwide especially in the tropics and subtropics. Plasmodium exhibits a complex life cycle …

Plasmodium berghei-Released Factor, PbTIP, Modulates the Host Innate Immune Responses

I Kalia, R Anand, A Quadiri, S Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
The Plasmodium parasite has to cross various immunological barriers for successful
infection. Parasites have evolved mechanisms to evade host immune responses, which …

A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein

U Iyamu, DF Vinals, B Tornyigah, E Arango… - Frontiers in Cellular …, 2023 - frontiersin.org
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …

Human Vγ9Vδ2 T Lymphocytes in the Immune Response to P. falciparum Infection

J Howard, I Zaidi, S Loizon… - Frontiers in …, 2018 - frontiersin.org
Malaria is an infectious disease caused by the protozoan parasite Plasmodium sp, the most
lethal being Plasmodium falciparum. Clinical malaria is associated with the asexual …

The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi

A Henning, SJ Clift, AL Leisewitz - Parasite immunology, 2020 - Wiley Online Library
To provide useful information based on the macropathology, histopathology and
immunohistochemical investigation in the spleens of dogs with Babesia rossi infection …

Examining cellular immune responses to inform development of a blood-stage malaria vaccine

DI Stanisic, MF Good - Parasitology, 2016 - cambridge.org
Naturally acquired immunity to the blood-stage of the malaria parasite develops slowly in
areas of high endemicity, but is not sterilizing. It manifests as a reduction in parasite density …

In silico screening of novel inhibitors of M17 Leucine Amino Peptidase (LAP) of Plasmodium vivax as therapeutic candidate

S Rout, RK Mahapatra - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Abstract M17 LAP (Leucine Amino Peptidase) plays an important role in the hydrolysis of
amino acids essential for growth and development of Plasmodium vivax (Pv), the pathogen …

Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria

JR Loughland, T Woodberry, MJ Boyle… - The Journal of …, 2019 - academic.oup.com
Background The malaria causing parasite Plasmodium subverts host immune responses by
several strategies including the modulation of dendritic cells (DCs). Methods In this study …

Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria

DS Khoury, D Cromer, SE Best, KR James, I Sebina… - Scientific reports, 2015 - nature.com
The best correlate of malaria severity in human Plasmodium falciparum (Pf) infection is the
total parasite load. Pf-infected humans could control parasite loads by two mechanisms …

Systems integration of innate and adaptive immunity

DE Zak, A Aderem - Vaccine, 2015 - Elsevier
The pathogens causing AIDS, malaria, and tuberculosis have proven too complex to be
overcome by classical approaches to vaccination. The complexities of human immunology …