Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …

Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking
its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO) …

The diverse physiological actions of the “biologic gases,” O2, CO, NO, and H2S, have
attracted much interest. Initially viewed as toxic substances, CO, NO, and H2S play important …

In the vasculature, reactive oxidant species, including reactive oxygen, nitrogen, or
halogenating species, and thiyl, tyrosyl, or protein radicals may oxidatively modify lipids and …

Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …

Heme is an essential prosthetic group in proteins that reside in virtually every subcellular
compartment performing diverse biological functions. Irrespective of whether heme is …

Background Heme is an essential molecule and plays vital roles in many biological
processes. The structural determination of a large number of heme proteins has made it …

Hemeoxygenase (HO) system is responsible for cellular heme degradation to biliverdin,
iron, and carbon monoxide. Two isoforms have been reported to date. Homologous HO‐1 …

FURUYAMA, K., KANEKO, K. and VARGAS V., PD Heme as a Magnificent Molecule with
Multiple Missions: Heme Determines Its Own Fate and Governs Cellular Homeostasis …